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Vitamin B12: Vitamin B12 deficiency can also lead to anemia, as well as fatigue

Global burden of knee osteoarthritis from 1990 to 2021: Trends, inequalities, and projections to 2035. PLoS One 20.6 (2025): e0320115

The etiology of megaloblastic anemia is multifactorial

What does this look like in practice

This is structurally similar to what has happened with private testosterone replacement clinics, which grew explosively over the last decade in part because middle-aged men with subclinical fatigue, low libido and low motivation kept being told by NHS GPs that their testosterone was in range. A private TRT clinic will write a prescription